名称:Grubbs Catalyst, 2nd Generation
同名:
(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium
CAS: [246047-72-3]
MW: 848.97
FW:C46H65Cl2N2PRu
外观:Pink Purple
MP:143.5-148.5 °C
Personal Protective Equipment:
Eyeshields, Gloves
Application:
1.Catalyst for ring-closing metathesis, cross
metathesis and ROMP able to
produce trisubstituted olefins via cross
metathesis, and ring closes
olefins with excellent functional group tolerance
and selectivity.
2.Enabling metathesis catalyst.
3.Used in the ring closing metathesis step of a
recent synthesis of BILN2061, a potent hepatitis C protease inhibitor.
4.Generation of unsaturated sultones from olefinic
sulfonates vis ring
closing metathesis.
5.Preparation of a macrocyclic β-Secretase inhibitor
via ring-closing
metathesis.
Reference:
1. Acc. Chem. Res. 34, 18, (2001)
2. Org. Lett. 1, 751, (1999)
3. Org. Lett. 1, 953, (1999)
4. J. Am. Chem. Soc. 126, 8110, (2004)
5. Angew. Chem. Int. Ed. Engl. 42, 4996, (2003)
6. J. Org. Chem. 71, 7133, (2006)
7. Tetrahedron 62, 9017, (2006)
8. J. Med. Chem. 49, 6147, (2006)
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